|
KMID : 1130320120550050164
|
|
Korean Journal of Pediatrics
2012 Volume.55 No. 5 p.164 ~ p.170
|
|
|
Successful and safe treatment of hemangioma with oral propranolol in a single institution
|
|
Chung Sun-Hee
Park Dong-Hyuk
Jung Hye-Lim
Shim Jae-Won
Kim Deok-Soo
Shim Jung-Yeon
Park Moon-Soo
Koo Hong-Hoe
|
|
|
Abstract
|
|
|
Purpose: Dramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined. The objective of this study is to describe and analyze the use of propranolol as a first-line treatment or as a single therapy in management of complicated hemangioma.
Methods: A retrospective chart review of eight patients diagnosed with hemangioma and treated with propranolol in Kangbuk Samsung Hospital from February 2010 to April 2011 was performed.
Results: Eight patients with hemangioma with functional impairment, cosmetic disfigurement, or rapid growth were treated with propranolol. Five patients had solitary facial hemangioma. The mean age of symptoms at onset was 5 weeks. The median age for starting propranolol treatment was 5.5 months. Propranolol at 2 mg/kg/day was finally administered in divided doses with a gradual increase. Significant regression was observed in seven patients, and shrinkage in size, softening in consistency, and decrease in redness were evident within 4 weeks. Among them, six patients were still taking propranolol, and one patient had stopped after 12 months. Other one patient did not show significant improvement with satisfactory result after 3 months of propranolol use. Treatment with propranolol was well tolerated and had few side effects. No rebound growth was observed in any of the patients.
Conclusion: We observed that use of propranolol was very effective in treatment of hemangioma without obvious adverse effects or relapse.
|
|
|
KEYWORD
|
|
|
Hemangioma, Propranolol, Treatment
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|